Vanheule E, Geerts AM, Van Huysse J, Schelfhout D, Praet M, Van Vlierberghe H, De Vos M, Colle I (2008) An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis.
Rodrigues SF, Fiel LA, Shimada AL, Pereira NR, Guterres SS, Pohlmann AR, Farsky SH (2016) Lipid-Core Nanocapsules act as a drug shuttle through the blood brain barrier and reduce glioblastoma after intravenous or Oral administration. Uchiyama MK, Deda DK, Rodrigues SF, Drewes CC, Bolonheis SM, Kiyohara PK, Toledo SP, Colli W, Araki K, Farsky SH (2014) In vivo and in vitro toxicity and anti-inflammatory properties of gold nanoparticle bioconjugates to the vascular system. Methods 127:53–61ĭellian M, Witwer BP, Salehi HA, Yuan F, Jain RK (1996) Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. Eur Cell Mater 32:202–215Ĭoles JA, Stewart-Hutchinson PJ, Myburgh E, Brewer JM (2017) The mouse cortical meninges are the site of immune responses to many different pathogens, and are accessible to intravital imaging. Laschke MW, Menger MD (2016) The dorsal skinfold chamber: a versatile tool for preclinical research in tissue engineering and regenerative medicine. Galanzha EI, Tuchin VV, Zharov VP (2007) Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening. Reif R, Ghallab A, Beattie L, Günther G, Kuepfer L, Kaye PM, Hengstler JG (2017) In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice. Miller MA, Weissleder R (2017) Imaging the pharmacology of nanomaterials by intravital microscopy: toward understanding their biological behavior. J Microsc 264:224–226ĭunn KW, Ryan JC (2017) Using quantitative intravital multiphoton microscopy to dissect hepatic transport in rats. J Pharmacol Toxicol Methods 61:102–112īurkovskiy I, Lehmann C, Jiang C, Zhou J (2016) Utilization of 3D printing for an intravital microscopy platform to study the intestinal microcirculation.
Hughes EL, Gavins FNE (2010) Troubleshooting methods: using intravital microscopy in drug research. Secklehner J, Lo Celso C, Carlin LM (2017) Intravital microscopy in historic and contemporary immunology. In this chapter, different experimental approaches are described to study the toxic effects and mechanisms of xenobiotics in the microcirculatory network. Therefore, IVM has been used to evaluate the effects and mechanisms of actions in the microvascular network caused by pharmacological or toxic chemical agents. By evaluating in situ microcirculatory network, IVM allows the visualization and quantification of physiological and pathological processes in the blood or in the adjacent tissues considering the whole system. Different tissues are surgically exposed to the visualization of the microvascular network in optical microscopies connected to video cameras and image software. Intravital microscopy (IVM) is an essential experimental approach for evaluating, in real time, cell interactions in the blood and rheological parameters in the microcirculation of the living animals.
0 kommentar(er)
